Feline infectious peritonitis is a viral disease of cats that is seen worldwide. In his most recent study, he successfully treated FIP in 25 of 31 cats using GS-441524. A few years back he approached pharmaceutical company, Gilead Sciences, with a hunch about using its antiviral drug—GS-441524—to combat FIP. ... GS-441524 GC-376 and Mutian. Pedersen added, “We chose to use GS-441424 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. At this time, we feel that Capella and Brava meet this criteria. Feline Infectious Peritonitis, FIP, is caused by a mutation of the typically benign Coronavirus (FCoV). For several weeks, the FIP community has been waiting for an announcement from Mutian that the company had made good on its promise to have FDA approval for its line of GS pills (called Mutian X), as an OTC drug under the FDA’s GRASE program. Subsequent, and yet to be published, trials with GS-441524 on 4 cats with severe neurological and/or ocular disease have shown GS to be also effective in these most difficult cases if the drug is given at a high enough dosage. The latter group has since revised its policy, and this month began referring pet owners seeking information about the unapproved treatments to FIP Warriors. Cats with neurological FIP may require a progressively higher dosage of 5-10 mg/kg. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and … The full report and some of what follows is highly technical so if you want to skip all that, you can scroll down where we summarize some of the results. For those with a high degree of confidence that their cat does have FIP, you can join FIP Warriors. Eight of the 60 cats survived over 200 days, and 4 of 60 survived over 300 days No historical control cat that suffered solely from dry FIP and not treated with PI lived longer than 200 days. Data was also acquired at half that dilution (1:60). Cats with neurological FIP may require a progressively higher dosage of 5-10 mg/kg. Edgar Maines already mentioned the unavailability of Niels Pedersen's breakthrough drug, which is unlikely to be available within the next five years. And I am happy to report that for the first time in history it appears that the grail might be somewhere within reach. There are two forms of the disease: wet form and dry form. With advent of COVID-19 on the world scene, people have become more acquainted with corona viruses and the drug Remdesivir – the first cousin to GS-441542 – the cure for FIP. Since GS is able to bind to RNA in the virus, it turns out that GS has an absorption profile that is similar to RNA in the same range of wavelengths. Vet Microbiol. We can see in plot below that the hero data very closely overlays the data for the 15mg/ml Standard. Veterinarians, who are under more legal and ethical constraints, may view the black market quite This sample from a “white cap” bottle is claimed to have a higher GS concentration (than the 15mg/ml standard) of 16.5 mg/ml. Keywords: FIP; GS-441524; Nucleoside analog; feline infectious peritonitis; field trial. Amazing Strange Rope Police – Vice Spider Vegas is a fantastic city simulator game in which you get to control a superhero that is like Spiderman. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. A Nanodrop passes light through a sample and measures the absorption of the light as a function of wavelength (color). Infekční peritonitida koček (též felinní infekční peritonitis, anglicky Feline Infectious Peritonitis, odtud běžně používaná zkratka FIP) je závažné infekční virové onemocnění koček způsobené kočičím koronavirem.Postihuje hlavně koťata do dvou let věku a pak staré kočky. January 20, 2020 Crafting the (near perfect) infomercial August 29, 2019 Worried about your cat’s liver and kidney values? 2018 Jun;219:226-233. V závislosti na úrovni buněčné imunity zvířete existuje onemocnění ve dvou formách: The first question is for your kitties weight, enter that and then select “Lbs” or “Kg” from the dropdown for what system your cat’s weight was measured in. ... Mutian GS for FIP, legal or not? Wichtige Botschaft von unserem Idol und Schirmherrn Prof. Niels C. P... edersen: I am happy to hear about the success of GS-441524 in Germany. The Nanodrop is an very sensitive instrument. While this is a closed group, they welcome anyone who faces FIP and wants to explore the use of the only available source of GS-441524 today.While these drugs are unregulated by any governmental agency, they are proving effective at treating FIP The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks. You can choose to become a superhero and save the day, or you can be the bad guy and become a supervillain instead! According to a paper published in the journal PLOS ONE, researchers from Kansas State University describe their success with an antiviral treatment for FIP that inhibits the virus from replicating and actually stops the the disease […] Throughout the course of treatment, remember to weigh your cat frequently and increase his/her dose accordingly with weight gain. I feel strongly that GS treatment by injection has the highest probability of curing your cat’s FIP and is the only treatment method backed by published research. The link below explains more about this disease and why this drug is difficult to get. Rusmira started him on GS treatment today as there’s no time to waste! We believe this method is very good for measuring concentration and also provides some data on purity. The recommended dosage of GS for cats with nonneurological FIP is 4 mg/kg, SC, once a day, for 12 weeks. The concentrations are quoted relative to 15mg/ml but the actual data shown here was taken at 1:120 dilution. The testing includes a mix of current GS brands and some older brands that were suspected of causing problems. The data discussed here was acquired with an instrument called a Nanodrop Spectrophotometer. It is a progressive disease that is almost always fatal. Feline infectious peritonitis or FIP is probably the number one fatal viral disease of young cats around the world. Common symptoms of the wet form of FIP include: Common symptoms of the dry form of FIP include: We have helped to save thousands of cats around the world in past 12 months. It is a . Clearly it is not 16.5mg/ml. The Nanodrop device is really designed to analyze RNA samples which have a characteristic absorption band in the UV (ultraviolet) which peaks near 260nm (nanometers). Capella and Brava: The plot below shows three data sets: the 15mg/ml standard, a recent random sample from a Capella shipment, and a recent random sample from a Brava shipment. Silvester has FiP The poor mite is struggling to breathe with fluid aro... und his lungs and he’s severely anemic. To determine actual concentration, we prepared Standard samples at various dilutions using GS powder provided by one of the more trusted GS brands. was found in the summer of 2019, shortly after a friend’s cat was diagnosed with Feline Infectious Peritonitis Virus (FIPV). Kate was among the early members of FIP Warriors, which launched in March as a GS-friendly alternative to FIP Fighters. What a sad, sorry world we have become if justification for wrongdoing makes you a hero. FIP (Feline Infectious Peritonitis) is one of the corona viruses. Clearly it is not 16.5mg/ml. All that said, if you decide you want to treat with one of the oral forms of GS, I will do my to help you locate a reputable oral form. REFERENCE: 1) Murphy BG, etc. Since the Standards were prepared and tested three times, we have high confidence that these results are correct to within 5%. We want to stress that this testing data should not be used as the sole means for selecting a brand. This group consists mostly of cat parents who have used or who are currently using GS to treat FIP. While RNA has a single absorption band near 260nm, GS has two absorption bands: one near 240nm and another one near 300nm. cats with dry FIP and 59 cats with similar dry FIP from the literature that had not been treated. It typically strikes kittens and young cats under 2 years of age, or older cats whose immune system has been stressed or otherwise compromised. They are equally tricky to diagnose. Our GS is treatment ready. As of July 2020, we have completed some useful testing on a number of GS samples. SAK II GS 441524 (16mg/ml) feline infectious peritonitis(FIP & FIPV), 5.2ml (2-1000 vials) € 59 Test Method: There are various possible methods that can be used to test GS samples. Further, the clinical results should include “tough” cases such as Ocular and neuro forms of FIP. Sadly our worst fears have came true! FIP Warriors has grown to more than 2,000 members in five months. Just open the package and begin the treatment. Below is a simple calculator for figuring out your GS-441524 dosage for your kitty. The surprising result we see here is that the actual concentrations for Capella and Brava are higher than the quoted 15mg/ml. FIP, or Feline Infectious Peritonitis, is a viral disease that affects cats. Please help Silvester fight FiP ️. Veterinarians, who are under more legal and ethical constraints, may view the black market quite differently from owners of cats suffering from FIP. With a clinical efficacy rate of 87%, GS-441524 from CureFip.com is the most effective treatment against wet and dry forms of Feline Infectious Peritonitis (FIP). Professor of Medicine. Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care. This compound is nearly identical Remdesivir. Much higher priority should be given to clinical results of a brand used to treat a large number of cats over the full 84 days of treatment and 84 dyas of post treatment observation. Thanks for asking. We will leave the purity discussion for the complete report. And to be fair, they show the greatest promise. and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. Framber Valdez posted a 26.4% K% over 70.2 IP in 2020, finishing with a 3.57 ERA (2.85 FIP, 2.94 xFIP, 3.23 SIERA) and 22nd in total points among starting pitchers. Distinguished professor Dr. Niels Pederson, legendary researcher at the University of California, Davis has been chasing a solution to FIP for many decades. However, a nearly identical compound GS-44124, has worked to treat FIP. Xi'an Holly Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. He says the drug works by blocking the virus’s ability to replicate. While this group does not represent or endorse any GS manufacturer, it can help connect you with different suppliers of GS441524. This is the what people mean when they caution owners that want to treat their cats that the available products are black market. GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug. FIP tips and startup tutorial; GS Calculator; Reading blood tests Question two is how many MG per KG of GS should your kitty have each day, in Question three you will select the concentration of you GS. GS Dose Calculator Please contact an FIP Warrior admin for assistance in determining the appropriate starting dose for your cat. In order to get GS samples in a good range for measurement, they had to be diluted at 1:120. We will refund you the full value of any unopened/unused vials should our GS prove to be ineffective in treating FIP in your cat. The higher the peak, the more light was absorbed indicating higher concentration. This sample from a “white cap” bottle is claimed to have a higher GS concentration (than the 15mg/ml standard) of 16.5 mg/ml. The actual testing was performed by an anonymous contributor at a nearby prestigious university. The recommended dosage of GS for cats with non-neurological FIP is 4 mg/kg, SC, once a day, for 12 weeks. It appears that FIP has been the hidden disease of cats for a long time, and that with a treatment, we are finally appreciating just how serious it is to our cats. FIP tips and startup tutorial Moved to FIP Slayer.com. See what these cats owners have to say about us. GS-441524 proved to be even more potent against FIP and provided hints that even neurological FIP was treatable. Our Guarantee is simple. A cure for FIP is the holy grail of veterinary medicine. "It very clear that GS-441524 is highly effective against coronavirus infection in cats," he explained. CUREFIP.COM was found in the summer of 2019, shortly after a friend’s cat was diagnosed with Feline Infectious Peritonitis Virus (FIPV).